Concepedia

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

Andrew Burchat, David W. Borhani, David J. Calderwood, Gavin C. Hirst, Biqin Li, Robert F. Stachlewitz

Bioorganic & Medicinal Chemistry Letters · 2005 · 85 citations · 4 references

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4

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

David B. Straus · Cell · 1992 · 1K citations

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Profound block in thymocyte development in mice lacking p56lck

Thierry Jo Molina, Kenji Kishihara, David P. Siderovski et al. · Nature · 1992 · 966 citations

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Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

Nicolai S. C. van Oers, Nigel Killeen, Arthur Weiss · The Journal of Experimental Medicine · 1996 · 332 citations · Full text

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A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection

David W. Borhani, David J. Calderwood, Michael Friedman et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 40 citations · Full text

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