Yoshiharu Mizui

Splicing factor SF3b as a target of the antitumor natural product pladienolide

Yoshihiko Kotake, Koji Sagane, Takashi Owa et al. · Nature Chemical Biology · 2007 · 649 citations · Full text

Oncogenic Agent, Medicine, Factor Sf3b +5

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Michael Seiler, Akihide Yoshimi, Rachel Darman et al. · Nature Medicine · 2018 · 491 citations · Full text

Tumor Biology, Medicine, Rna Splicing +9

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

Rachel Darman, Michael Seiler, Anant A. Agrawal et al. · Cell Reports · 2015 · 453 citations · Full text

Genetics, Rna Splicing, Molecular Biology +17

Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors

Ferry A.L.M. Eskens, Francisco Javier Ramos, Herman Burger et al. · Clinical Cancer Research · 2013 · 246 citations · Full text

Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107 III. In Vitro and In Vivo Antitumor Activities

Yoshiharu Mizui, Takashi Sakai, Masao Iwata et al. · The Journal of Antibiotics · 2004 · 185 citations · Full text