Takashi Owa

Splicing factor SF3b as a target of the antitumor natural product pladienolide

Yoshihiko Kotake, Koji Sagane, Takashi Owa et al. · Nature Chemical Biology · 2007 · 659 citations · Full text

Medicine, Molecular Biology, Oncology +9

Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study

Antoîne Italiano, Jean‐Charles Soria, Maud Toulmonde et al. · The Lancet Oncology · 2018 · 614 citations

Medicine, Oncology, Pharmacology +12

Selective degradation of splicing factor CAPERα by anticancer sulfonamides

Taisuke Uehara, Yukinori Minoshima, Koji Sagane et al. · Nature Chemical Biology · 2017 · 379 citations

Medicine, Molecular Biology, Pharmacology +14

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia

Eric Wang, Sydney X. Lu, Alessandro Pastore et al. · Cancer Cell · 2019 · 370 citations · Full text

Life Sciences, Molecular Biology, Oncology +14

A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

Christian A. Hassig, Jeffrey K. Tong, Tracey C. Fleischer et al. · Proceedings of the National Academy of Sciences · 1998 · 367 citations · Full text

Life Sciences, Molecular Biology, Epigenetics +12