Valerjans Kauss

A Practical Synthesis of tert-Alkylamines via the Ritter Reaction with Chloroacetonitrile

Aigars Jirgensons, Valerjans Kauss, Ivars Kalvinsh et al. · Synthesis · 2000 · 55 citations

Chemical Engineering, Practical Synthesis, Ritter Reaction +10

Positive and Negative Modulation of Group I Metabotropic Glutamate Receptors

Maksims Vanejevs, Claudia Jatzke, Steffen Renner et al. · Journal of Medicinal Chemistry · 2008 · 49 citations · Full text

Subtype 1, Neurotransmitter, Neurotransmission +21

Virtual Screening for Selective Allosteric mGluR1 Antagonists and Structure–Activity Relationship Investigations for Coumarine Derivatives

Tobias Noeske, Aigars Jirgensons, Igors Starchenkovs et al. · ChemMedChem · 2007 · 36 citations

Drug Target, Coumarine Scaffold, Coumarine Derivatives +17

Synergism of virtual screening and medicinal chemistry: Identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1

Tobias Noeske, Dina Trifanova, Valerjans Kauss et al. · Bioorganic & Medicinal Chemistry · 2009 · 26 citations · Full text

Medicinal Chemistry, Virtual Screening, Drug Target +12

Discovery, synthesis, and structure–activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators

Holger Kubas, Udo Meyer, Bjoern Krueger et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 13 citations · Full text

Negative Allosteric Modulators, Molecular Pharmacology, Biochemistry +9