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Synergism of virtual screening and medicinal chemistry: Identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1

Medicinal ChemistryVirtual ScreeningDrug TargetBiochemistryFunctional SelectivityMedicineNatural SciencesRational Drug DesignNeuropharmacologyPharmacotherapyDrug DevelopmentPharmacologyPharmaceutical ChemistryAllosteric AntagonistsDrug Discovery