Aigars Jirgensons

Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate

Olga Bobiļeva, Raitis Bobrovs, I. Kanepe et al. · ACS Medicinal Chemistry Letters · 2021 · 65 citations · Full text

Fragment-Based Discovery of 2-Aminoquinazolin-4(3<i>H</i>)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV

Dace Rasiņa, Mārtiņš Otikovs, Ja̅nis Leita̅ns et al. · Journal of Medicinal Chemistry · 2015 · 64 citations · Full text

Antiparasitic Agent, Malaria, Chemical Biology +20

Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target

Chrislaine Withers‐Martinez, Catherine Suárez, Simone Fulle et al. · International Journal for Parasitology · 2012 · 58 citations · Full text

Protein Assembly, Malaria, Proteasome +17

Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit

Kristaps Jaudzems, Kaspars Tārs, Gundars Maurops et al. · ACS Medicinal Chemistry Letters · 2014 · 55 citations · Full text

Inhibitory Activity, Medicinal Chemistry, Plasmepsin Inhibitory Activity +15

A Practical Synthesis of tert-Alkylamines via the Ritter Reaction with Chloroacetonitrile

Aigars Jirgensons, Valerjans Kauss, Ivars Kalvinsh et al. · Synthesis · 2000 · 55 citations

Chemical Engineering, Practical Synthesis, Ritter Reaction +10