Concepedia

Discovery, synthesis, and structure–activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators

Holger Kubas, Udo Meyer, Bjoern Krueger, Mirko Hechenberger, Maksims Vanejevs, Ronalds Zemribo, Valerjans Kauss, R. F. Ambartsumova, Ilya Pyatkin, Alexey I. Polosukhin,

Bioorganic & Medicinal Chemistry Letters · 2013 · 14 citations · 27 references

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27

Extended-Connectivity Fingerprints

David Rogers, Mathew Hahn · Journal of Chemical Information and Modeling · 2010 · 7.6K citations

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The Properties of Known Drugs. 1. Molecular Frameworks

Guy W. Bemis, Mark A. Murcko · Journal of Medicinal Chemistry · 1996 · 2.5K citations

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PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results

Steven L. Dixon, Alexander M. Smondyrev, Eric H. Knoll et al. · Journal of Computer-Aided Molecular Design · 2006 · 1.2K citations

, , +17

Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods:  An Analysis of ALOGP and CLOGP Methods

Arup K. Ghose, Vellarkad N. Viswanadhan, John J. Wendoloski · The Journal of Physical Chemistry A · 1998 · 794 citations

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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr et al. · Neuropharmacology · 1999 · 720 citations

, , +7