Lauren Dare

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong et al. · Journal of Medicinal Chemistry · 2017 · 464 citations · Full text

Drug Target, Immunology, Cell Death +22

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

Scott B. Berger, Viera Kasparcova, Sandy Hoffman et al. · The Journal of Immunology · 2014 · 368 citations · Full text

DNA-Encoded Library Screening Identifies Benzo[<i>b</i>][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Philip A. Harris, Bryan W. King, Deepak Bandyopadhyay et al. · Journal of Medicinal Chemistry · 2016 · 268 citations · Full text

Drug Target, Immunology, Kinase Inhibitors +17

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

Joshua N. Finger, John D. Lich, Lauren Dare et al. · Journal of Biological Chemistry · 2012 · 253 citations · Full text

Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

George B. Stroup, Michael W. Lark, Daniel F. Veber et al. · Journal of Bone and Mineral Research · 2001 · 153 citations