David C. McGowan

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Pierre Raboisson, Herman de Kock, Åsa Rosenquist et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 136 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

Xuan G. Luong, Sarah Stevens, Andreas Jekle et al. · PLoS ONE · 2020 · 68 citations · Full text

Medicine, Endocrinology, Pharmacology +14

Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck:  Synthesis, SAR, and in Vivo Anti-Inflammatory Activity

Erin F. DiMauro, John Newcomb, Joseph J. Nunes et al. · Journal of Medicinal Chemistry · 2006 · 67 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

George P. Liao, Eman M. M. Abdelraheem, Constantinos G. Neochoritis et al. · Organic Letters · 2015 · 62 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +14

Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck:  Synthesis, SAR, and in Vivo Antiinflammatory Activity

Matthew W. Martin, John Newcomb, Joseph J. Nunes et al. · Journal of Medicinal Chemistry · 2006 · 61 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16