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Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

DOIFull Paper Access

61

Citations

30

References

2015

Year

George P. Liao, Eman M. M. Abdelraheem, Constantinos G. Neochoritis, Katarzyna Kurpiewska, Justyna Kalinowska‐Tłuścik, David C. McGowan, Alexander Dömlingꝉ
Organic Letters

Abstract

The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings.

References

YearCitations

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