J. Howard Jones

Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-<i>N</i>-acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications

M.C. Van Zandt, Michael L. Jones, David Gunn et al. · Journal of Medicinal Chemistry · 2005 · 222 citations · Full text

Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators

Bin Ma, Brian S. Lucas, Andrew G. Capacci et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 42 citations · Full text

Medicine, Chemistry, Pharmacology +3

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Bin Ma, Doug Marcotte, Murugan Paramasivam et al. · PLoS ONE · 2016 · 37 citations · Full text

Mitophagy, Apoptosis, Cell Death +16

Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors

Martin Himmelbauer, Zhili Xin, J. Howard Jones et al. · Journal of Medicinal Chemistry · 2019 · 34 citations · Full text

Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo

Tamara Halkina, Jaclyn L. Henderson, Edward Yin-Shiang Lin et al. · Journal of Medicinal Chemistry · 2021 · 32 citations · Full text