Brian S. Lucas

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Sean Caenepeel, Sean P. Brown, Brian Belmontes et al. · Cancer Discovery · 2018 · 419 citations · Full text

Medicine, Oncology, Pharmacology +14

Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Daqing Sun, Zhihong Li, Yosup Rew et al. · Journal of Medicinal Chemistry · 2014 · 296 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

Gabriela Chiosis, Merna N. Timaul, Brian S. Lucas et al. · Chemistry & Biology · 2001 · 284 citations · Full text

Medicine, Molecular Biology, Oncology +13

Development of a Purine-Scaffold Novel Class of Hsp90 Binders that Inhibit the Proliferation of Cancer Cells and Induce the Degradation of Her2 Tyrosine Kinase

Gabriela Chiosis, Brian S. Lucas, Аlexander А. Shtil et al. · Bioorganic & Medicinal Chemistry · 2002 · 194 citations

Medicine, Medicinal Chemistry, Oncology +11

Targeting Wide-Range Oncogenic Transformation via PU24FCl, a Specific Inhibitor of Tumor Hsp90

Maria Vilenchik, David B. Solit, Andrea Basso et al. · Chemistry & Biology · 2004 · 170 citations · Full text

Medicine, Cancer Biology, Oncology +12