Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators

Bin Ma, Brian S. Lucas, Andrew G. Capacci, +8

Bioorganic & Medicinal Chemistry Letters

MedicineChemistryPharmacologyPharmaceutical ChemistryDrug Discovery +1

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Bin Ma, Doug Marcotte, Murugan Paramasivam, +10

PLoS ONE

MitophagyApoptosisCell DeathCpd 1Receptor Tyrosine Kinase +14

Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases

Bin Ma, Tonika Bohnert, Kevin L. Otipoby, +21

Journal of Medicinal Chemistry

Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis

Brian T. Hopkins, Eris Bame, Bekim Bajrami, +32

Journal of Medicinal Chemistry

ImmunologyNeurological ProgressImmunotherapySelective Btk InhibitorReceptor Tyrosine Kinase +14

A modified Curtius reaction: an efficient and simple method for direct isolation of free amine

Bin Ma, Wen‐Cherng Lee

Tetrahedron Letters

Chemical EngineeringNovel OrganocatalystsEngineeringDirect IsolationCatalysis +5

Next‐generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells

Eris Bame, Hao Tang, Jeremy C. Burns, +31

Clinical & Translational Immunology

Investigation on dye separation mechanism in covalent-organic framework membranes with molecular dynamics simulation

Xin Zhu, Bin Ma, Yuqing Ai, +4

Microporous and Mesoporous Materials

Membrane StructureChemical EngineeringMembrane FormationEngineeringCovalent Bonded Framework +9

Toxic effects of arsenic trioxide on <italic>Echinococcus granulosus</italic> protoscoleces through ROS production, and Ca<sup>2+</sup>-ER stress-dependent apoptosis

Jiajie Li, Guangyao Tang, Wenjuan Qin, +6

Acta Biochimica et Biophysica Sinica

Toxic EffectsLipid PeroxidationPathologyCell DeathRedox Biology +19

Enhancing the Gene Transfection of Poly(β-amino ester)/DNA Polyplexes by Modular Manipulation of Amphiphilicity

Jiahao Shi, Yuhe Zhang, Bin Ma, +6

ACS Applied Materials & Interfaces

EngineeringResponsive PolymersMolecular BiologyGene DeliveryBiomedical Engineering +19

How climate, landscape, and economic changes increase the exposure of Echinococcus Spp.

Xiaoyu Di, Shuo Li, Bin Ma, +4

BMC Public Health