Robert Narquizian

β-Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

Hans Hilpert, Wolfgang Guba, Thomas J. Woltering et al. · Journal of Medicinal Chemistry · 2013 · 137 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((<i>S</i>)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

Emmanuel Pinard, Alexander Alanine, Daniela Alberati et al. · Journal of Medicinal Chemistry · 2010 · 134 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APP_LondonMice

Helmut Jacobsen, Laurence Ozmen, Antonello Caruso et al. · Journal of Neuroscience · 2014 · 96 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Patrizio Mattei, Markus Boehringer, Patrick Di Giorgio et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-<i>a</i>]phthalazines as GABA_AReceptor Agonists at the α₃Subunit

Michael G. N. Russell, Robert W. Carling, John Atack et al. · Journal of Medicinal Chemistry · 2005 · 61 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17