Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain

Philipp J. Kahle, Manuela Neumann, Laurence Ozmen, +10

Journal of Neuroscience

Subcellular FractionationSubcellular LocalizationMolecular BiologySynaptic SignalingSocial Sciences +14

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions

Ralf Bartenschlager, L Ahlborn-Laake, Jan Mous, +1

Journal of Virology

Virus StructureViral ReplicationBiochemistryHepatitis C VirusNatural Sciences +13

Antiviral effects of recombinant tumour necrosis factor in vitro

Jürgen Mestan, W. Digel, Sibylle Mittnacht, +5

Nature

Antiviral EffectsImmunologyAntiviral TherapyAntiviral ResponseVirology +3

Kinetic and structural analyses of hepatitis C virus polyprotein processing

Ralf Bartenschlager, L Ahlborn-Laake, Jan Mous, +1

Journal of Virology

Viral ReplicationAmino AcidsImmunologyMolecular BiologyViral Structural Protein +17

Hyperphosphorylation and insolubility of α‐synuclein in transgenic mouse oligodendrocytes

Philipp J. Kahle, Manuela Neumann, Laurence Ozmen, +11

EMBO Reports

Neurodegenerative DiseasesMolecular NeuroscienceTransgenic Mouse OligodendrocytesDegenerative PathologyMolecular Neurobiology +4

Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model

Philipp J. Kahle, Manuela Neumann, Laurence Ozmen, +12

American Journal Of Pathology

Neurodegenerative DiseasesMolecular NeuroscienceImmunologyMolecular BiologyDegenerative Pathology +6

PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation

John Richards, Guy A. Higgins, Abdel‐Mouttalib Ouagazzal, +11

Journal of Neuroscience

Abeta DepositsCoexpressing Hps2mutSocial SciencesNeuroinflammationAlzheimer's Disease +16

Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959

Helmut Jacobsen, Kaya Yasargil, Dean L. Winslow, +4

Virology

Viral ReplicationHuman RetrovirusPathogenesisImmunologyAntiviral Response +8

Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with <i>In vivo</i> Efficacy and Pharmacodynamic Properties

Leopoldo Luistro, Wei He, Melissa Smith, +14

Cancer Research

Ro4929097 Ic50Cancer BiologyTumor BiologyMolecular PharmacologyPharmacodynamic Properties +15

In Vivo Resistance to a Human Immunodeficiency Virus Type 1 Proteinase Inhibitor: Mutations, Kinetics, and Frequencies

Helmut Jacobsen, Markus Hänggi, Michael Ott, +5

The Journal of Infectious Diseases