Alexander Alanine

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

Mark B. Pepys, J. Herbert, W. L. Hutchinson et al. · Nature · 2002 · 536 citations

Alzheimer's Disease, Medicine, Pharmacological Depletion +5

A novel antibiotic class targeting the lipopolysaccharide transporter

Claudia Zampaloni, Patrizio Mattei, Konrad Bleicher et al. · Nature · 2024 · 259 citations · Full text

Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Olivier Roche, Petra Schneider, Jochen Zuegge et al. · Journal of Medicinal Chemistry · 2001 · 250 citations

Engineering, Hit Identification, Pattern Discovery +24

A Virtual Screening Method for Prediction of the hERG Potassium Channel Liability of Compound Libraries

Olivier Roche, Gerhard Trube, Jochen Zuegge et al. · ChemBioChem · 2002 · 160 citations

Medicinal Chemistry, Drug Design, Bioanalysis +16

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((<i>S</i>)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

Emmanuel Pinard, Alexander Alanine, Daniela Alberati et al. · Journal of Medicinal Chemistry · 2010 · 133 citations · Full text

Psychotropic Medication, Herg Channel Selectivity, Psychopharmacology +18