Effect of Bitopertin, a Glycine Reuptake Inhibitor, on Negative Symptoms of Schizophrenia

Daniel Umbricht, Daniela Alberati, Meret Martin‐Facklam, +9

JAMA Psychiatry

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((<i>S</i>)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

Emmanuel Pinard, Alexander Alanine, Daniela Alberati, +25

Journal of Medicinal Chemistry

Psychotropic MedicationHerg Channel SelectivityPsychopharmacologyCompound 10APharmacotherapy +16

Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia

Daniela Alberati, Jean‐Luc Moreau, Judith A. Lengyel, +8

Neuropharmacology

PsychiatryMedicinePsychopharmacologySchizophreniaNeuropharmacology +7

Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal–lesioned rats: reversal by glycine and a glycine transporter inhibitor

Gwenaëlle Le Pen, James N.C. Kew, Daniela Alberati, +3

Biological Psychiatry

Synaptic PlasticityNeurophysiologyMedicineSynaptic TransmissionPhysiology +12

Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression

Laetitia Gabernet, Meike Pauly-Evers, Cornelia Schwerdel, +6

Neuroscience Letters

Molecular PharmacologyNmda Receptor FunctionMolecular PhysiologySignal TransductionBiochemistry +8

Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice

Tamás L. Horváth, Sabrina Diano, Suzanne Miyamoto, +12

International Journal of Obesity

ObesityMetabolic SyndromeInflammationKnockout MouseSignal Transduction +8

Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers

Carsten Hofmann, Flavia Pizzagalli, Christophe Boetsch, +6

Psychopharmacology

Glycine Reuptake InhibitorsNeurophysiologyMedicineHealthy VolunteersCerebrospinal Fluid +6

Effects of GlyT1 inhibition on erythropoiesis and iron homeostasis in rats

Michael Winter, Jürgen Funk, Annette Körner, +6

Experimental Hematology

InflammationGlyt1 InhibitionHeme HomeostasisIron MetabolismPhysiology +9

Glycine Transporter Type I (GlyT1) Inhibitor, Bitopertin: A Journey from Lab to Patient

Emmanuel Pinard, Edilio Borroni, Annette Koerner, +2

CHIMIA International Journal for Chemistry

Molecular PharmacologyGlycine Transporter-1MedicineImmunologyGlycine Transporter Type +10

Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors

Emmanuel Pinard, Simona Ceccarelli, Henri Stalder, +1

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryGlyt1 InhibitorsBiochemistryMedicine +9