Wolfgang Guba

VolSurf: a new tool for the pharmacokinetic optimization of lead compounds

Gabriele Cruciani, Manuel Pastor, Wolfgang Guba · European Journal of Pharmaceutical Sciences · 2000 · 426 citations

Lead Compounds, Pharmaceutical Science, Pharmaceutical Research +10

Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Olivier Roche, Petra Schneider, Jochen Zuegge et al. · Journal of Medicinal Chemistry · 2001 · 250 citations

Engineering, Hit Identification, Pattern Discovery +24

Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

K. Jaeger, S. Bruenle, Tobias Weinert et al. · Cell · 2019 · 141 citations · Full text

β-Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

Hans Hilpert, Wolfgang Guba, Thomas J. Woltering et al. · Journal of Medicinal Chemistry · 2013 · 136 citations · Full text

Neurochemical Biomarkers, Pharmacotherapy, Alzheimer ’ +24

Torsion Angle Preferences in Druglike Chemical Space: A Comprehensive Guide

Christin Schärfer, Tanja Schulz‐Gasch, Hans‐Christian Ehrlich et al. · Journal of Medicinal Chemistry · 2013 · 134 citations · Full text

Torsion Library, Pharmaceutical Science, Biomolecular Structure Prediction +22