Concepedia

VolSurf: a new tool for the pharmacokinetic optimization of lead compounds

Gabriele Cruciani, Manuel Pastor, Wolfgang Guba

European Journal of Pharmaceutical Sciences · 2000 · 426 citations · 21 references

DOI

Concepts

References

21

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

, , +16

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

P. J. Goodford · Journal of Medicinal Chemistry · 1985 · 2.6K citations

, , +17

Cross-Validatory Estimation of the Number of Components in Factor and Principal Components Models

Svante Wold · Technometrics · 1978 · 2.5K citations

, , +10

Physicochemical High Throughput Screening:  Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

Manfred Kansy, Frank Senner, Klaus Gubernator · Journal of Medicinal Chemistry · 1998 · 1.3K citations

, , +16

MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening

Jennifer D. Irvine, Lori H. Takahashi, Karen Lockhart et al. · Journal of Pharmaceutical Sciences · 1999 · 976 citations

, , +13