Concepedia

Lead Compound Discovery

Lead Compound Discovery is the process of identifying a biologically active natural product with desirable pharmacological properties from a natural source or extract, serving as a starting point for drug development.

996

Publications

61.4K

Citations

6.5K

Authors

1.3K

Institutions

Publications per year

2017–2026

311

Parents

Publications

996

Lead- and drug-like compounds: the rule-of-five revolution

Christopher A. Lipinski · Drug Discovery Today Technologies · 2004 · 6.1K citations

, , +14

Identifying and Characterizing Binding Sites and Assessing Druggability

Thomas A. Halgren · Journal of Chemical Information and Modeling · 2009 · 1.8K citations

, , +13

Thousands of chemical starting points for antimalarial lead identification

Francisco‐Javier Gamo, Laura M. Sanz, Jaume Vidal et al. · Nature · 2010 · 1K citations

, , +12

New Method for Fast and Accurate Binding‐site Identification and Analysis

Tom Halgren · Chemical Biology & Drug Design · 2007 · 903 citations

, , +17

Is There a Difference between Leads and Drugs? A Historical Perspective

Tudor I. Oprea, A. M. Davis, Simon J. Teague et al. · Journal of Chemical Information and Computer Sciences · 2001 · 775 citations

, , +12

1–5 of 996

Authors

6.5K

  1. MK
    Marcel Kaiser

    Swiss Tropical and Public Health Institute, Switzerland

    7 publications · 296 citations

    7

    h-index

  2. RB
    Reto Brun

    Swiss Tropical and Public Health Institute, Switzerland

    6 publications · 210 citations

    6

    h-index

  3. AB
    Andrew Baxter

    British American Tobacco (United Kingdom), United Kingdom

    5 publications · 321 citations

    5

    h-index

  4. YM
    Yovani Marrero‐Ponce

    Universidad Central "Marta Abreu" de las Villas (UCLV), Cuba

    5 publications · 202 citations

    5

    h-index

  5. JM
    Jeremy Murray

    WuXi AppTec (China), China

    5 publications · 371 citations

    5

    h-index

1–5 of 6.5K

Institutions

1.3K

  1. Chinese Academy of Sciences

    Beijing, China

    20 h-index

    156 publications

    4.6K citations

  2. Shanghai Institute of Materia Medica

    Pudong, China

    17 h-index

    84 publications

    2.7K citations

  3. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    16 h-index

    82 publications

    5.1K citations

  4. University of Chinese Academy of Sciences

    Beijing, China

    16 h-index

    54 publications

    1.5K citations

  5. China Pharmaceutical University

    Nanjing, China

    14 h-index

    96 publications

    2.5K citations

  6. University of California, San Francisco

    San Francisco, United States

    12 h-index

    52 publications

    4.3K citations

  7. Pfizer (United States)

    New York, United States

    12 h-index

    111 publications

    13.3K citations

  8. University of Illinois Chicago

    Chicago, United States

    11 h-index

    62 publications

    4.4K citations

1–8 of 1.3K

Venues

  1. Journal of Medicinal Chemistry

    119 publications · 7.9K citations

    52

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    52 publications · 1.8K citations

    26

    h-index

  3. Bioorganic & Medicinal Chemistry

    30 publications · 1.2K citations

    21

    h-index

  4. Journal of Chemical Information and Modeling

    JCIM · 27 publications · 2.7K citations

    20

    h-index

  5. European Journal of Medicinal Chemistry

    30 publications · 897 citations

    19

    h-index

1–5