Kay Eckersley

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Jason G. Kettle, Husam Alwan, Michał Biśta et al. · Journal of Medicinal Chemistry · 2016 · 136 citations · Full text

Medicine, Oncology, Pharmacology +6

Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2

Richard A. Ward, Nicola Colclough, Mairi Challinor et al. · Journal of Medicinal Chemistry · 2015 · 105 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts.

D C Blakey, P. J. Burke, D. Huw Davies et al. · PubMed · 1996 · 60 citations

Pharmacy, Oncology, Pharmacology +16

Engineered human carboxypeptidase B enzymes that hydrolyse hippuryl-L- glutamic acid: reversed-polarity mutants

Michael D. Edge, Clive Forder, J. Hennam et al. · Protein Engineering Design and Selection · 1998 · 32 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Enzymatic Characterisation of USP7 Deubiquitinating activity and Inhibition

Jonathan D.J. Wrigley, Kay Eckersley, Ian M. Hardern et al. · Cell Biochemistry and Biophysics · 2011 · 27 citations

Life Sciences, Biochemistry, Molecular Biology +11