P. J. Burke

A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma.

Nicholas J. Petrelli, L Herrera, Youcef M. Rustum et al. · Journal of Clinical Oncology · 1987 · 449 citations

Oncology, Pharmacology, Clinical Trials +15

Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia.

Eric K. Rowinsky, Alex A. Adjei, Ross C. Donehower et al. · Journal of Clinical Oncology · 1994 · 131 citations

Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy

Caroline J. Springer, Robert I. Dowell, P. J. Burke et al. · Journal of Medicinal Chemistry · 1995 · 90 citations

Combinatorial Chemistry, Pharmaceutical Science, Bioorganic Chemistry +18

Pharmacology and toxicity of high-dose cytarabine by 72-hour continuous infusion.

Ross C. Donehower, J. E. Karp, P. J. Burke · PubMed · 1986 · 89 citations

Toxic Effects, Pharmacotherapy, Metronomic Chemotherapy +17

Antibody directed enzyme prodrug therapy (ADEPT): clinical report.

K. D. Bagshawe, Shruti Sharma, Caroline J. Springer et al. · PubMed · 1992 · 79 citations

Pathology, Pharmacotherapy, Advanced Colorectal Cancer +16