Jeffrey Cohen

Potent nonsteroidal progesterone receptor agonists: Synthesis and SAR study of 6-aryl benzoxazines

Puwen Zhang, Eugene A. Terefenko, Andrew Fensome et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 116 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +10

Discovery of 1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-<i>d</i>]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against <i>BRAF</i> or <i>RAS</i> Mutant Tumor Cells

James R. Henry, Michael D. Kaufman, Sheng-Bin Peng et al. · Journal of Medicinal Chemistry · 2015 · 84 citations · Full text

Kinase Inhibitors, Pharmaceutical Chemistry, Tumor Biology +20

New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles

Andrew Fensome, Reinhold H. W. Bender, Jeffrey Cohen et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 73 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Medicine +7

SAR studies of 6-aryl-1,3-dihydrobenzimidazol-2-ones as progesterone receptor antagonists

Eugene A. Terefenko, Jeffrey C. Kern, Andrew Fensome et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 57 citations · Full text

Progesterone Receptor Antagonists, Medicine, Mechanism Of Action +4

Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1)

Bryan H. Norman, Peter A. Lander, Joseph M. Gruber et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 54 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Drug Target +13