Karl Welzenbach

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

Gabriele Weitz‐Schmidt, Karl Welzenbach, Volker Brinkmann et al. · Nature Medicine · 2001 · 1K citations

Inflammation, Cytokine, Immunology +8

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain 1 1Edited by F. E. Cohen

Joerg Kallen, Karl Welzenbach, Paul Ramage et al. · Journal of Molecular Biology · 1999 · 256 citations

Lfa-1 Inhibition, Molecular Pharmacology, Signal Transduction +13

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

Dominik Feuerbach, Patrick Schindler, Carmen Barske et al. · Neuroscience Letters · 2017 · 179 citations

Histidine 157, Cleaves Trem2, G Protein-coupled Receptor +7

The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation

Jean-Pierre Evenou, Jürgen Wagner, Gerhard Zenke et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 159 citations

Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

Rainer Albert, Klaus Hinterding, Volker Brinkmann et al. · Journal of Medicinal Chemistry · 2005 · 150 citations · Full text

Bioorganic Chemistry, Biologically Active Species, Vivo Phosphorylation +18