Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

Gabriele Weitz‐Schmidt, Karl Welzenbach, Volker Brinkmann, +6

Nature Medicine

InflammationCytokineImmunologyImmune RegulationLeukocyte Function Antigen-1 +6

X-Ray Structure of the hRORα LBD at 1.63 Å

Joerg Kallen, Jean-Marc Schlaeppi, Francis Bitsch, +4

Structure

X-ray CrystallographyX-ray SpectroscopyEngineeringBiochemistryNatural Sciences +6

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain 1 1Edited by F. E. Cohen

Joerg Kallen, Karl Welzenbach, Paul Ramage, +6

Journal of Molecular Biology

Lfa-1 InhibitionMolecular PharmacologySignal TransductionMolecular PhysiologyNatural Sciences +11

Evidence for Ligand-independent Transcriptional Activation of the Human Estrogen-related Receptor α (ERRα)

Joerg Kallen, Jean-Marc Schlaeppi, Francis Bitsch, +7

Journal of Biological Chemistry

Crystal Structure of the Human RORα Ligand Binding Domain in Complex with Cholesterol Sulfate at 2.2 Å

Joerg Kallen, Jean-Marc Schlaeppi, Francis Bitsch, +2

Journal of Biological Chemistry

Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors

Philipp Holzer, Keiichi Masuya, Pascal Furet, +13

Journal of Medicinal Chemistry

Dihydroisoquinolinone DerivativeDrug TargetMolecular BiologyPharmacotherapyTumor Biology +16

Chemical modification of rapamycin: the discovery of SDZ RAD

Richard Sedrani, Sylvain Cottens, Joerg Kallen, +1

Transplantation Proceedings

MedicineChemical ModificationDrug DevelopmentChemical BiologyPharmacology +3

The X‐ray structure of a tetrapeptide bound to the active site of human cyclophilin A

Joerg Kallen, Malcolm D. Walkinshaw

FEBS Letters

Protein ChemistryX‐ray StructureA-2.3 AProtein AssemblyBiochemistry +13

Cyclosporin A—cyclophilin complex formation A model based on X‐ray and NMR data

Claus Spitzfaden, H. P. WEBER, Werner Braun, +5

FEBS Letters

Protein AssemblyMolecular BiologyChemical BiologyCyclic Csa MoleculeProtein Folding +14

Crystal Structure of Human Estrogen-related Receptor α in Complex with a Synthetic Inverse Agonist Reveals Its Novel Molecular Mechanism

Joerg Kallen, René Lattmann, René Beerli, +7

Journal of Biological Chemistry