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ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

Histidine 157Cleaves Trem2G Protein-coupled ReceptorMain SheddaseImmunologyReceptor (Biochemistry)Gene ExpressionMedicineCell BiologyCell Signaling