The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

Volker Brinkmann, Michael D. Davis, Christopher E. Heise, +10

Journal of Biological Chemistry

ImmunologyImmune RegulationImmunologic MechanismImmunotherapySphingosine Kinase +14

[111In-DTPA-D-Phe1]-octreotide, a potential radiopharmaceutical for imaging of somatostatin receptor-positive tumors: synthesis, radiolabeling and in vitro validation

Willem H. Bakker, Rainer Albert, Christian Bruns, +9

Life Sciences

EngineeringOncologic ImagingPotential RadiopharmaceuticalTheranosticsMolecular Imaging +8

Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

Rainer Albert, Klaus Hinterding, Volker Brinkmann, +11

Journal of Medicinal Chemistry

Bioorganic ChemistryBiologically Active SpeciesVivo PhosphorylationImmunologyMedicinal Chemistry +16

The somatostatin receptor-targeted radiotherapeutic [ 90 Y-DOTA- d Phe 1 ,Tyr 3 ]octreotide ( 90 Y-SMT 487) eradicates experimental rat pancreatic CA 20948 tumours

Barbara Stolz, Gisbert Weckbecker, Peter Smith‐Jones, +3

European Journal of Nuclear Medicine and Molecular Imaging

Tumor BiologyY-smt 487Pancreatic CancerMedicinePathology +7

The Sphingosine 1-Phosphate Receptor Agonist FTY720 Differentially Affects the Sequestration of CD4+/CD25+ T-Regulatory Cells and Enhances Their Functional Activity

Elżbieta Sawicka, Gerald Dubois, Gábor Járai, +7

The Journal of Immunology

Receptor Agonist Fty720Cd4+/cd25+ T CellsT-regulatory CellImmunologyImmune Regulation +18

Discovery of 3-(1<i>H</i>-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes

Jürgen Wagner, Peter Matt, Richard Sedrani, +13

Journal of Medicinal Chemistry

Gallium-67/gallium-68-[DFO]-octreotide--a potential radiopharmaceutical for PET imaging of somatostatin receptor-positive tumors: synthesis and radiolabeling in vitro and preliminary in vivo studies.

Peter Smith‐Jones, Barbara Stolz, Christian Bruns, +4

PubMed

A Novel Somatostatin Mimic with Broad Somatotropin Release Inhibitory Factor Receptor Binding and Superior Therapeutic Potential

Ian Lewis, W. Bauer, Rainer Albert, +4

Journal of Medicinal Chemistry

Medicinal ChemistryGrowth HormoneBiochemistryNovel Somatostatin MimicMedicine +10

Carbohydrate triflates: reaction with nitrite, leading directly to epi-hydroxy compounds

Rainer Albert, K. Dax, Robert W. Link, +1

Carbohydrate Research

EngineeringBiochemistryNatural SciencesFluorous SynthesisOrganic Chemistry +3

FTY720 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Drug Resistance

Hiroshi Yasui, Teru Hideshima, Noopur Raje, +14

Cancer Research