Radwan El‐Haggar

Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, <i>in vitro</i> biological evaluation, and QSAR studies

Ahmed Sabt, Omaima M. Abdelhafez, Radwan El‐Haggar et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2018 · 107 citations · Full text

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

Wagdy M. Eldehna, Mahmoud F. Abo-Ashour, Alessio Nocentini et al. · European Journal of Medicinal Chemistry · 2018 · 98 citations · Full text

Tail Hydrophobic Interactions, Combinatorial Chemistry, Medicinal Chemistry +11

Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations

Wagdy M. Eldehna, Mahmoud A. El Hassab, Mahmoud F. Abo-Ashour et al. · Bioorganic Chemistry · 2021 · 97 citations

Medicinal Chemistry, Medicine, Molecular Dynamics Investigations +10

3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies

Abdulsalam A. M. Alkhaldi, Mohammad M. Al‐Sanea, Alessio Nocentini et al. · European Journal of Medicinal Chemistry · 2020 · 76 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +10

Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells

Andrea Petreni, Alessandro Bonardi, Carrie L. Lomelino et al. · European Journal of Medicinal Chemistry · 2020 · 70 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +9