Jumpei Aida

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Jessica Vincent, Carolina Adura, Pu Gao et al. · Nature Communications · 2017 · 360 citations · Full text

Primary Macrophages, Innate Immune System, Immunology +21

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Lodoe Lama, Carolina Adura, Wei Xie et al. · Nature Communications · 2019 · 269 citations · Full text

Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors

Jumpei Aida, Makoto Fushimi, Tomokazu Kusumoto et al. · Journal of Medicinal Chemistry · 2018 · 64 citations · Full text

Magl Enzyme, Medicinal Chemistry, Piperazinyl Pyrrolidin-2-one Core +15

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2<i>H</i>-benzo[<i>b</i>][1,4]oxazin-6-yl Moiety

Shuhei Ikeda, Hideyuki Sugiyama, Hidekazu Tokuhara et al. · Journal of Medicinal Chemistry · 2021 · 36 citations · Full text

Design and Identification of a GPR40 Full Agonist (<b>SCO-267</b>) Possessing a 2-Carbamoylphenyl Piperidine Moiety

Hideki Furukawa, Yasufumi Miyamoto, Yasuhiro Hirata et al. · Journal of Medicinal Chemistry · 2020 · 30 citations · Full text