Nickel/Lewis Acid-Catalyzed Cyanoesterification and Cyanocarbamoylation of Alkynes

Yasuhiro Hirata, Akira Yada, Eiji Morita, +4

Journal of the American Chemical Society

Asymmetric CatalysisBeta-cyano EsterCross-coupling ReactionEnantioselective SynthesisEngineering +10

Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides

Yasuhiro Hirata, Tomoya Yukawa, Natsuko Kashihara, +2

Journal of the American Chemical Society

Allylcyanation of Alkynes:  Regio- and Stereoselective Access to Functionalized Di- or Trisubstituted Acrylonitriles

Yoshiaki Nakao, Tomoya Yukawa, Yasuhiro Hirata, +3

Journal of the American Chemical Society

Chemical EngineeringCross-coupling ReactionPi-allylnickel SpeciesEngineeringStereoselective Access +11

Cyanoesterification of 1,2-Dienes:  Synthesis and Transformations of Highly Functionalized α-Cyanomethylacrylate Esters

Yoshiaki Nakao, Yasuhiro Hirata, Tamejiro Hiyama

Journal of the American Chemical Society

Nickel/BPh₃‐Catalyzed Alkynylcyanation of Alkynes and 1,2‐Dienes: An Efficient Route to Highly Functionalized Conjugated Enynes

Yoshiaki Nakao, Yasuhiro Hirata, Masaaki Tanaka, +1

Angewandte Chemie International Edition

Chemical EngineeringCross-coupling ReactionEngineeringHeterocyclicBinary Catalysis +12

Cyanoesterification of 1,2-Dienes Catalyzed by Nickel

Yasuhiro Hirata, Tomohiko Inui, Yoshiaki Nakao, +1

Journal of the American Chemical Society

Chemical EngineeringCyanoformate EstersEngineeringAlkene MetathesisCross-coupling Reaction +7

Alkynylcyanation of alkynes and dienes catalyzed by nickel

Yasuhiro Hirata, Masaaki Tanaka, Akira Yada, +2

Tetrahedron

Cross-coupling ReactionEngineeringAlkene MetathesisOrganic ChemistryOrganometallic Catalysis +2

Stannylative Cycloaddition of Enynes Catalyzed by Palladium−Iminophosphine

Yoshiaki Nakao, Yasuhiro Hirata, Shinjiro Ishihara, +4

Journal of the American Chemical Society

Enantioselective SynthesisEngineeringHeterocyclicConjugated EnynesAlcyopterosin N +7

Design and Identification of a GPR40 Full Agonist (<b>SCO-267</b>) Possessing a 2-Carbamoylphenyl Piperidine Moiety

Hideki Furukawa, Yasufumi Miyamoto, Yasuhiro Hirata, +15

Journal of Medicinal Chemistry

Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents

Takuto Kojima, Yasutomi Asano, Osamu Kurasawa, +21

Bioorganic & Medicinal Chemistry

Cancer Therapeutic AgentsMedicineAnti-cancer AgentDrug DevelopmentBiomolecular Engineering +4