Airway Basophil and Mast Cell Density in Patients with Bronchial Asthma: Relationship to Bronchial Hyperresponsiveness

Takeshi Koshino, Yasuo Arai, Yasufumi Miyamoto, +7

Journal of Asthma

Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor

Yasufumi Miyamoto, Yoshihiro Banno, Tatsuhiko Fujimoto, +18

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryPharmacotherapyChemical BiologyMedicinal Chemistry +14

Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554

Yoshihiro Banno, Yasufumi Miyamoto, Mitsuru Sasaki, +15

Bioorganic & Medicinal Chemistry

Medicinal ChemistryUnique InteractionBioorganic ChemistryBiochemistryNatural Sciences +8

SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity

Hikaru Ueno, Ryo Ito, Shinichi Abe, +13

Journal of Pharmacology and Experimental Therapeutics

Design and Identification of a GPR40 Full Agonist (<b>SCO-267</b>) Possessing a 2-Carbamoylphenyl Piperidine Moiety

Hideki Furukawa, Yasufumi Miyamoto, Yasuhiro Hirata, +15

Journal of Medicinal Chemistry

A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats

Hitoshi Yasuda, Masanobu Sonobe, Ikuo Hatanaka, +8

Biochemical and Biophysical Research Communications

Streptozocin-diabetic RatsNeurophysiologyInsulin ManagementDiabetesPhysiology +10

Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554

Hironobu Maezaki, Yoshihiro Banno, Yasufumi Miyamoto, +16

Bioorganic & Medicinal Chemistry

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences +8

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

Yasufumi Miyamoto, Yoshihiro Banno, Tatsuhiko Fujimoto, +16

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistry3-Pyridylacetamide DerivativesMedicineNatural Sciences +7

Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents

Takuto Kojima, Yasutomi Asano, Osamu Kurasawa, +21

Bioorganic & Medicinal Chemistry

Cancer Therapeutic AgentsMedicineAnti-cancer AgentDrug DevelopmentBiomolecular Engineering +4

GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve

Hikaru Ueno, Ryo Ito, Shinichi Abe, +8

PLoS ONE

Food IntakeCaloric RestrictionInsulin SignalingGastrointestinal Peptide HormoneIntegrative Physiology +20