Discovery of [<i>cis</i>-3-({(5<i>R</i>)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1<i>H</i>-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5<i>H</i>)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist

Mitsunori Kono, Atsuko Ochida, Tsuneo Oda, +23

Journal of Medicinal Chemistry

PharmacotherapyPharmaceutical ChemistryPre-clinical PharmacologyMolecular PharmacologyMedicinal Chemistry +14

Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor

Yasufumi Miyamoto, Yoshihiro Banno, Tatsuhiko Fujimoto, +18

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryPharmacotherapyChemical BiologyMedicinal Chemistry +14

Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554

Yoshihiro Banno, Yasufumi Miyamoto, Mitsuru Sasaki, +15

Bioorganic & Medicinal Chemistry

Medicinal ChemistryUnique InteractionBioorganic ChemistryBiochemistryNatural Sciences +8

Reactions of alkynylselenonium salts with sodium benzenesulfinate

Tadashi Kataoka, Yoshihiro Banno, Shinichi Watanabe, +1

Tetrahedron Letters

Organic ChemistrySodium BenzenesulfinateChemistryReaction Process

Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist

Tatsuhiko Fujimoto, Kentaro Rikimaru, Koichiro Fukuda, +18

ACS Medicinal Chemistry Letters

Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554

Hironobu Maezaki, Yoshihiro Banno, Yasufumi Miyamoto, +16

Bioorganic & Medicinal Chemistry

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences +8

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

Yasufumi Miyamoto, Yoshihiro Banno, Tatsuhiko Fujimoto, +16

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistry3-Pyridylacetamide DerivativesMedicineNatural Sciences +7

Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist

Tomoya Yukawa, Yoshi Nara, Mitsunori Kono, +20

Journal of Medicinal Chemistry

ImmunologyImmunotherapeuticsMolecular PharmacologyMedicinal ChemistryHelix 12 +15

Design of potent dipeptidyl peptidase IV (DPP-4) inhibitors by employing a strategy to form a salt bridge with Lys554

Hironobu Maezaki, Michiko Tawada, Yoshihiro Banno, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryBiochemistryNatural SciencesMedicine +9

Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives

Mitsunori Kono, Tsuneo Oda, Michiko Tawada, +20

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryNovel Tetrahydroisoquinoline DerivativesMedicine +9