Pyrene-Fused Porphyrins: Annulation Reactions of <i>meso</i>-Pyrenylporphyrins

Osamu Yamane, Ken-ichi Sugiura, Hitoshi Miyasaka, +6

Chemistry Letters

Chemical EngineeringEngineeringPhotochemistryOxidation PotentialsCyclodextrin Production +8

TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice

Hiroshi Yukitake, Tatsuhiko Fujimoto, Takashi Ishikawa, +6

Pharmacology Biochemistry and Behavior

Molecular PhysiologySignal TransductionFunctional SelectivityMedicinePhysiology +9

The first Janus [2]rotaxane

Tatsuhiko Fujimoto, Yoshiteru Sakata, Takahiro Kaneda

Chemical Communications

Nmr Methodsα-Cyclodextrin 1DerivativesEngineeringHistorical Archaeology +9

Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor

Yasufumi Miyamoto, Yoshihiro Banno, Tatsuhiko Fujimoto, +18

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryPharmacotherapyChemical BiologyMedicinal Chemistry +14

Photoswitching of the association of a permethylated α-cyclodextrin-azobenzene dyad forming a Janus [2]pseudorotaxane

Tatsuhiko Fujimoto, Asao Nakamura, Yoshihisa Inoue, +2

Tetrahedron Letters

PhotochemistryNatural SciencesMechanistic PhotochemistryMolecular BiologyOrganic Chemistry +4

New Large-Scale Preparations of Versatile 6-<i>O</i>-Monotosyl and 6-Monohydroxy Permethylated α-, β-, and γ-Cyclodextrins

Takahiro Kaneda, Tatsuhiko Fujimoto, J. GOTO, +5

Chemistry Letters

Bioorganic ChemistryEngineeringNatural SciencesCyclodextrin ProductionDiversity-oriented Synthesis +8

Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist

Tatsuhiko Fujimoto, Kentaro Rikimaru, Koichiro Fukuda, +18

ACS Medicinal Chemistry Letters

Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists

Tatsuhiko Fujimoto, Jun Kunitomo, Yoshihide Tomata, +6

Bioorganic & Medicinal Chemistry Letters

BiochemistryFunctional SelectivityMedicineMechanism Of ActionPharmacological Agent +3

Systematic Synthesis of Porphyrin Dimers Linked by Conjugated Oligoacetylene Bridges

Kazuya Nakamura, Tatsuhiko Fujimoto, S. Takara, +5

Chemistry Letters

Combinatorial ChemistryA SeriesEngineeringOrganic ChemistryChemistry +6

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

Yasufumi Miyamoto, Yoshihiro Banno, Tatsuhiko Fujimoto, +16

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistry3-Pyridylacetamide DerivativesMedicineNatural Sciences +7