Eric E. Swayze

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary<i>N</i>-acetyl galactosamine improves potency 10-fold in mice

Thazha P. Prakash, Mark J. Graham, Jinghua Yu et al. · Nucleic Acids Research · 2014 · 597 citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +17

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

Sarah L. DeVos, Rebecca L. Miller, Kathleen M. Schoch et al. · Science Translational Medicine · 2017 · 531 citations · Full text

Life Sciences, Neurology, Neuroscience +16

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

Eric E. Swayze, Andrew Siwkowski, Edward V. Wancewicz et al. · Nucleic Acids Research · 2006 · 461 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA

Charles Allerson, Namir Sioufi, Russell Jarres et al. · Journal of Medicinal Chemistry · 2005 · 442 citations

Pharmacy, Chemical Biology, Molecular Biology +17

Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial

Catherine J. Mummery, Anne Börjesson‐Hanson, D. Blackburn et al. · Nature Medicine · 2023 · 318 citations · Full text

Life Sciences, Neurology, Neuroscience +17