Edward V. Wancewicz

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

Magdalini Polymenidou, Clotilde Lagier‐Tourenne, Kasey R. Hutt et al. · Nature Neuroscience · 2011 · 1.3K citations · Full text

Neuronal Vulnerability, Molecular Neuroscience, Medicine +10

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

Holly Kordasiewicz, Lisa M. Stanek, Edward V. Wancewicz et al. · Neuron · 2012 · 758 citations · Full text

Knockout Mouse, Molecular Biology, Degenerative Disease +7

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

Clotilde Lagier‐Tourenne, Magdalini Polymenidou, Kasey R. Hutt et al. · Nature Neuroscience · 2012 · 732 citations · Full text

Protein Function, Amyotrophic Lateral Sclerosis, Natural Sciences +9

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

Eric E. Swayze, Andrew Siwkowski, Edward V. Wancewicz et al. · Nucleic Acids Research · 2006 · 450 citations · Full text

Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals

Punit P. Seth, Andrew Siwkowski, Charles Allerson et al. · Journal of Medicinal Chemistry · 2008 · 263 citations · Full text