Holly Kordasiewicz

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

Magdalini Polymenidou, Clotilde Lagier‐Tourenne, Kasey R. Hutt et al. · Nature Neuroscience · 2011 · 1.3K citations · Full text

Neuronal Vulnerability, Molecular Neuroscience, Medicine +10

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

Holly Kordasiewicz, Lisa M. Stanek, Edward V. Wancewicz et al. · Neuron · 2012 · 758 citations · Full text

Knockout Mouse, Molecular Biology, Degenerative Disease +7

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

Sarah L. DeVos, Rebecca L. Miller, Kathleen M. Schoch et al. · Science Translational Medicine · 2017 · 510 citations · Full text

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

Eveline S. Arnold, Shuo‐Chien Ling, Stephanie C. Huelga et al. · Proceedings of the National Academy of Sciences · 2013 · 482 citations · Full text

Rna Processing, Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis +15

Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial

Catherine J. Mummery, Anne Börjesson‐Hanson, D. Blackburn et al. · Nature Medicine · 2023 · 288 citations · Full text