Shuo‐Chien Ling

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

Magdalini Polymenidou, Clotilde Lagier‐Tourenne, Kasey R. Hutt et al. · Nature Neuroscience · 2011 · 1.3K citations · Full text

Neuronal Vulnerability, Molecular Neuroscience, Medicine +10

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

Clotilde Lagier‐Tourenne, Magdalini Polymenidou, Kasey R. Hutt et al. · Nature Neuroscience · 2012 · 732 citations · Full text

Protein Function, Amyotrophic Lateral Sclerosis, Natural Sciences +9

Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration

Clotilde Lagier‐Tourenne, Michael W. Baughn, Frank Rigo et al. · Proceedings of the National Academy of Sciences · 2013 · 551 citations · Full text

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Sporadic Als +13

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron et al. · Neuron · 2016 · 530 citations · Full text

Natural Sciences, Als/ftd-linked Repeat Expansions, Molecular Biology +5

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

Eveline S. Arnold, Shuo‐Chien Ling, Stephanie C. Huelga et al. · Proceedings of the National Academy of Sciences · 2013 · 482 citations · Full text

Rna Processing, Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis +15