Jie Jiang

Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration

Clotilde Lagier‐Tourenne, Michael W. Baughn, Frank Rigo et al. · Proceedings of the National Academy of Sciences · 2013 · 551 citations · Full text

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Sporadic Als +13

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron et al. · Neuron · 2016 · 530 citations · Full text

Natural Sciences, Als/ftd-linked Repeat Expansions, Molecular Biology +5

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Yong‐Jie Zhang, Tania F. Gendron, Jonathan C. Grima et al. · Nature Neuroscience · 2016 · 316 citations · Full text

Protein Function, Signal Transduction, Nucleocytoplasmic Transport Proteins +11

Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

Qiang Zhu, Jie Jiang, Tania F. Gendron et al. · Nature Neuroscience · 2020 · 224 citations · Full text

C9orf72 Function, Amyotrophic Lateral Sclerosis, Medicine +4

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

Weiwei Cheng, Shaopeng Wang, Alexander A. Mestre et al. · Nature Communications · 2017 · 217 citations · Full text