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Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron, Shahram Saberi, Melissa McAlonis‐Downes, Amanda Seelman, Jennifer E. Stauffer, Paymaan Jafar‐Nejad, Kevin Drenner, Derek Schulte,

Neuron · 2016 · 540 citations · 59 references

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59

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Alan E. Renton, Elisa Majounie, Adrian J. Waite et al. · Neuron · 2011 · 4.5K citations · Full text

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The <i>C9orf72</i> GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

Kohji Mori, Shih‐Ming Weng, Thomas Arzberger et al. · Science · 2013 · 1.3K citations

, , +17

A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types

Myriam Heiman, Anne Schaefer, Shiaoching Gong et al. · Cell · 2008 · 1.2K citations · Full text

, , +16

Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS

Peter E.A. Ash, Kevin F. Bieniek, Tania F. Gendron et al. · Neuron · 2013 · 1.1K citations · Full text

, , +7

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

Ke Zhang, Christopher J. Donnelly, Aaron R. Haeusler et al. · Nature · 2015 · 1K citations

, , +5