Concepedia

Repeat Expansion Targeting

Repeat Expansion Targeting is a molecular editing strategy that selectively directs allele-specific genome editing tools to pathogenic repetitive DNA sequences in order to preferentially modify mutant alleles carrying expanded repeats while preserving normal-length repeats.

34

Publications

3K

Citations

243

Authors

86

Institutions

Publications per year

2017–2026

14

Parents

Publications

34

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron et al. · Neuron · 2016 · 540 citations · Full text

, , +15

Identification of a (CUG)n Triplet Repeat RNA-Binding Protein and Its Expression in Myotonic Dystrophy

Lubov Timchenko, J. W. Miller, Nikolai A. Timchenko et al. · Nucleic Acids Research · 1996 · 460 citations · Full text

, , +16

Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9

Ranjan Batra, David A. Nelles, Elaine Pirie et al. · Cell · 2017 · 257 citations · Full text

, , +13

Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs

Jiaxin Hu, Masayuki Matsui, Keith T. Gagnon et al. · Nature Biotechnology · 2009 · 240 citations · Full text

, , +14

Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons

Chul‐Yong Park, Tomer Halevy, Dongjin R. Lee et al. · Cell Reports · 2015 · 179 citations · Full text

, , +17

1–5 of 34

Authors

243

  1. MD
    Matthew D. Disney

    Scripps Research Institute, United States

    5 publications · 268 citations

    5

    h-index

  2. HO
    Hailey Olafson

    University of Florida, United States

    3 publications · 230 citations

    3

    h-index

  3. TF
    Tania F. Gendron

    Mayo Clinic in Florida, United States

    3 publications · 640 citations

    3

    h-index

  4. WJ
    Włodzimierz J. Krzyżosiak

    Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poland

    3 publications · 129 citations

    3

    h-index

  5. AF
    Agnieszka Fiszer

    Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poland

    3 publications · 129 citations

    3

    h-index

1–5 of 243

Institutions

86

  1. University of Florida

    Gainesville, United States

    6 h-index

    27 publications

    5K citations

  2. Scripps Research Institute

    San Diego, United States

    6 h-index

    38 publications

    2.2K citations

  3. The University of Texas Southwestern Medical Center

    Dallas, United States

    4 h-index

    20 publications

    2.4K citations

  4. Institute of Bioorganic Chemistry, Polish Academy of Sciences

    Poznan, Poland

    4 h-index

    15 publications

    571 citations

  5. Mayo Clinic in Florida

    Jacksonville, United States

    3 h-index

    9 publications

    1.9K citations

  6. Southwestern Medical Center

    Lawton, United States

    3 h-index

    13 publications

    760 citations

  7. The University of Osaka

    Osaka, Japan

    3 h-index

    7 publications

    154 citations

  8. Ionis Pharmaceuticals (United States)

    Carlsbad, United States

    2 h-index

    9 publications

    4K citations

1–8 of 86

Venues

  1. Nucleic Acids Research

    5 publications · 636 citations

    5

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 354 citations

    3

    h-index

  3. 1

    h-index

  4. ACS Chemical Biology

    1 publications · 20 citations

    1

    h-index

  5. Translational Vision Science & Technology

    TVST · 1 publications · 34 citations

    1

    h-index

1–5