Concepedia

Allele-specific Editing

Allele-Specific Editing is a genome editing technique that selectively targets and modifies one allele of a gene while leaving the other allele(s) unchanged, typically by exploiting sequence differences such as single nucleotide polymorphisms to achieve discrimination between allelic variants.

141

Publications

11.3K

Citations

1.2K

Authors

379

Institutions

Publications per year

2017–2026

109

Parents

Children

Publications

141

In vivo genome editing using a high-efficiency TALEN system

Victoria M. Bedell, Ying Wang, Jarryd M. Campbell et al. · Nature · 2012 · 920 citations · Full text

, , +13

Directed evolution of adenine base editors with increased activity and therapeutic application

Nicole M. Gaudelli, Dieter K. Lam, Holly A. Rees et al. · Nature Biotechnology · 2020 · 530 citations

, , +16

Allele-aware chromosome-level genome assembly and efficient transgene-free genome editing for the autotetraploid cultivated alfalfa

Haitao Chen, Yan Zeng, Yongzhi Yang et al. · Nature Communications · 2020 · 488 citations · Full text

, , +17

Optimized gene editing technology for <i>Drosophila melanogaster</i> using germ line-specific Cas9

Xingjie Ren, Jin Sun, Benjamin E. Housden et al. · Proceedings of the National Academy of Sciences · 2013 · 433 citations · Full text

, , +14

Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos

Michael V. Zuccaro, Jia Xu, Carl A. Mitchell et al. · Cell · 2020 · 323 citations · Full text

, , +7

1–5 of 141

Authors

1.2K

  1. UK
    Ulrich Koller

    EB House Austria, Austria

    3 publications · 126 citations

    3

    h-index

  2. NM
    Nicole M. Gaudelli

    Beam Therapeutics (United States), United States

    3 publications · 665 citations

    3

    h-index

  3. AL
    Alexander Liquori

    Beam Therapeutics (United States), United States

    3 publications · 665 citations

    3

    h-index

  4. IM
    Ian M. Slaymaker

    Broad Institute, United States

    3 publications · 665 citations

    3

    h-index

  5. HA
    Holly A. Rees

    Howard Hughes Medical Institute, United States

    3 publications · 665 citations

    3

    h-index

1–5 of 1.2K

Institutions

379

  1. Harvard University

    Cambridge, United States

    14 h-index

    82 publications

    10.2K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    10 h-index

    17 publications

    1.7K citations

  3. Massachusetts General Hospital

    Boston, United States

    9 h-index

    33 publications

    3.9K citations

  4. University of Chinese Academy of Sciences

    Beijing, China

    9 h-index

    39 publications

    3.7K citations

  5. Broad Institute

    Cambridge, United States

    8 h-index

    32 publications

    2.8K citations

  6. Chinese Academy of Sciences

    Beijing, China

    8 h-index

    47 publications

    4.8K citations

  7. University of California, San Francisco

    San Francisco, United States

    5 h-index

    18 publications

    809 citations

  8. Dana-Farber Cancer Institute

    Boston, United States

    4 h-index

    26 publications

    1.5K citations

1–8 of 379

Venues

  1. Nature Communications

    9 publications · 1.2K citations

    9

    h-index

  2. Scientific Reports

    8 publications · 541 citations

    8

    h-index

  3. The CRISPR Journal

    6 publications · 270 citations

    6

    h-index

  4. Molecular Therapy

    5 publications · 542 citations

    5

    h-index

  5. Nucleic Acids Research

    5 publications · 125 citations

    5

    h-index

1–5