Concepedia

Allele-specific Knockout

Allele-Specific Knockout is a genome editing technique that selectively inactivates one allele of a gene while preserving the function of the other allele, typically by exploiting sequence differences such as single nucleotide polymorphisms to achieve targeted disruption.

48

Publications

3.6K

Citations

379

Authors

126

Institutions

Publications per year

2017–2026

14

Parents

Publications

48

Identification of 5-Lipoxygenase as a Major Gene Contributing to Atherosclerosis Susceptibility in Mice

Margarete Mehrabian, Hooman Allayee, Jack Wong et al. · Circulation Research · 2002 · 421 citations · Full text

, , +15

Hypertrophic Cardiomyopathy in Cardiac Myosin Binding Protein-C Knockout Mice

Samantha P. Harris, Christopher R. Bartley, Timothy A. Hacker et al. · Circulation Research · 2002 · 384 citations · Full text

, , +12

Allele-specific activation of genetically engineered receptors.

Catherine D. Strader, T. J. Gaffney, Elizabeth E. Sugg et al. · Journal of Biological Chemistry · 1991 · 233 citations · Full text

, , +17

Disruption of the <i>c/ebp</i>α Gene in Adult Mouse liver

Ying‐Hue Lee, Brian Sauer, Peter F. Johnson et al. · Molecular and Cellular Biology · 1997 · 183 citations · Full text

, , +16

Allele-Specific Suppression of a Defective Brassinosteroid Receptor Reveals a Physiological Role of UGGT in ER Quality Control

Hua Jin, Zhenyan Yan, Kyoung Hee Nam et al. · Molecular Cell · 2007 · 182 citations · Full text

, , +11

1–5 of 48

Authors

379

  1. GR
    Gareth R. Howell

    Jackson Laboratory, United States

    2 publications · 36 citations

    2

    h-index

  2. SS
    Shaogang Sun

    Shanghai Institutes for Biological Sciences, China

    1 publications · 13 citations

    1

    h-index

  3. ML
    Mark L. McCleland

    Florida Hospital Cancer Institute, United States

    1 publications · 80 citations

    1

    h-index

  4. YW
    Yimin Wuriyanghai

    Kyoto University, Japan

    1 publications · 89 citations

    1

    h-index

  5. KH
    Konrad Hochedlinger

    Massachusetts General Hospital, United States

    1 publications · 50 citations

    1

    h-index

1–5 of 379

Institutions

126

  1. Harvard University

    Cambridge, United States

    4 h-index

    14 publications

    1.5K citations

  2. Iowa State University

    Ames, United States

    3 h-index

    8 publications

    597 citations

  3. National Institutes of Health

    Bethesda, United States

    2 h-index

    5 publications

    731 citations

  4. Tufts University

    Medford, United States

    2 h-index

    3 publications

    50 citations

  5. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    2 h-index

    4 publications

    456 citations

  6. Massachusetts General Hospital

    Boston, United States

    2 h-index

    8 publications

    601 citations

  7. University of Dundee

    Dundee, United Kingdom

    2 h-index

    8 publications

    462 citations

  8. Columbia University

    New York, United States

    2 h-index

    3 publications

    120 citations

1–8 of 126

Venues

  1. PLoS ONE

    5 publications · 223 citations

    5

    h-index

  2. genesis

    4 publications · 204 citations

    4

    h-index

  3. Molecular and Cellular Biology

    MCB · 4 publications · 476 citations

    4

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 353 citations

    3

    h-index

  5. Nature Communications

    3 publications · 105 citations

    3

    h-index

1–5