Paymaan Jafar‐Nejad

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

Lindsay A. Becker, Brenda Huang, Gregor Bieri et al. · Nature · 2017 · 562 citations · Full text

Lifespan Extension, Knockout Mouse, Molecular Neuroscience +11

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron et al. · Neuron · 2016 · 530 citations · Full text

Natural Sciences, Als/ftd-linked Repeat Expansions, Molecular Biology +5

ATAXIN-1 Interacts with the Repressor Capicua in Its Native Complex to Cause SCA1 Neuropathology

Yung C. Lam, Aaron B. Bowman, Paymaan Jafar‐Nejad et al. · Cell · 2006 · 325 citations · Full text

Neurodegenerative Diseases, Signal Transduction, Molecular Neuroscience +13

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

Janghoo Lim, Juan Crespo-Barreto, Paymaan Jafar‐Nejad et al. · Nature · 2008 · 307 citations · Full text

Protein Chemistry, Protein Function, Signal Transduction +11

Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis

Vladislav A. Korobeynikov, Alexander K. Lyashchenko, Beatriz Blanco-Redondo et al. · Nature Medicine · 2022 · 249 citations · Full text