Melissa McAlonis‐Downes

Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration

Clotilde Lagier‐Tourenne, Michael W. Baughn, Frank Rigo et al. · Proceedings of the National Academy of Sciences · 2013 · 557 citations · Full text

Life Sciences, Neurobiology, Neurology +14

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron et al. · Neuron · 2016 · 540 citations · Full text

Life Sciences, Genetics, Molecular Genetics +15

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

Eveline S. Arnold, Shuo‐Chien Ling, Stephanie C. Huelga et al. · Proceedings of the National Academy of Sciences · 2013 · 496 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

Koji Yamanaka, Séverine Boillée, Elizabeth A. Roberts et al. · Proceedings of the National Academy of Sciences · 2008 · 307 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

Jone López‐Erauskin, Takahiro Tadokoro, Michael W. Baughn et al. · Neuron · 2018 · 242 citations · Full text

Life Sciences, Neurology, Neuroscience +17