Matthew J. Meyer

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial

Stefan J. Schaller, Matthew Anstey, Manfred Blobner et al. · The Lancet · 2016 · 726 citations

Critical Care Management, Goal-directed Mobilisation, Critical Care Medicine +8

A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases

Matthew J. Meyer · The EMBO Journal · 1999 · 518 citations · Full text

Orf Virus, Angiogenesis, Immunology +9

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

Gregory R. Hoffman, Rami Rahal, Frank P. Buxton et al. · Proceedings of the National Academy of Sciences · 2014 · 405 citations · Full text

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 284 citations · Full text

Allosteric Inhibition, Drug Target, Shp2 Inhibition +20