Gary Fairley

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Jon Winter, Malcolm Anderson, Kevin Blades et al. · Journal of Medicinal Chemistry · 2015 · 120 citations

Life Sciences, Biochemistry, Molecular Biology +17

Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2

Richard A. Ward, Nicola Colclough, Mairi Challinor et al. · Journal of Medicinal Chemistry · 2015 · 105 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Richard A. Ward, Mark J. Anderton, Paul A. Bethel et al. · Journal of Medicinal Chemistry · 2019 · 78 citations · Full text

Medicine, Oncology, Pharmacology +17

Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point

Richard A. Ward, Paul A. Bethel, Calum Cook et al. · Journal of Medicinal Chemistry · 2017 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Diverse Heterocyclic Scaffolds as Allosteric Inhibitors of AKT

Jason G. Kettle, S Brown, Claire Crafter et al. · Journal of Medicinal Chemistry · 2012 · 51 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17