Calum Cook

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

Bernard Barlaam, Robert Casella, Justin Cidado et al. · Journal of Medicinal Chemistry · 2020 · 104 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Richard A. Ward, Mark J. Anderton, Paul A. Bethel et al. · Journal of Medicinal Chemistry · 2019 · 78 citations · Full text

Medicine, Oncology, Pharmacology +17

Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology

Frederick W. Goldberg, Jason G. Kettle, Gillian M. Lamont et al. · Journal of Medicinal Chemistry · 2022 · 56 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point

Richard A. Ward, Paul A. Bethel, Calum Cook et al. · Journal of Medicinal Chemistry · 2017 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

(1<i>R</i>,2<i>R</i>)-<i>N</i>-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-<i>b</i>]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis

Alexander G. Dossetter, Howard A. Beeley, Jonathan Bowyer et al. · Journal of Medicinal Chemistry · 2012 · 39 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16