Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases

Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.

Rod Humerickhouse, K Lohrbach, Lin Li et al. · PubMed · 2000 · 356 citations

Life Sciences, Biochemistry, Pharmacology +14

Substrate Specificity of Carboxylesterase Isozymes and Their Contribution to Hydrolase Activity in Human Liver and Small Intestine

Teruko Imai, Megumi Taketani, Mayumi Shii et al. · Drug Metabolism and Disposition · 2006 · 279 citations

Life Sciences, Biochemistry, Molecular Biology +15

Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan.

Guang Xu, Wanghai Zhang, Howard L. McLeod · PubMed · 2002 · 278 citations

Medicine, Cancer Biology, Pharmacology +12

Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel

Deshi Shi, Jian Yang, Dongfang Yang et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 277 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Antiplatelet Agents Aspirin and Clopidogrel Are Hydrolyzed by Distinct Carboxylesterases, and Clopidogrel Is Transesterificated in the Presence of Ethyl Alcohol

Man Tang, Madhu Mukundan, Jian Yang et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 250 citations

Medicine, Biochemistry, Pharmacology +9