Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan.

Guang Xu, Wanghai Zhang, Howard L. McLeod

PubMed

Tumor BiologyGallbladder TumorOncologyOncogenic AgentMedicine +12

Branched-chain Amino Acids Are Essential in the Regulation of PHAS-I and p70 S6 Kinase by Pancreatic β-Cells

Guang Xu, Guim Kwon, Connie A. Marshall, +3

Journal of Biological Chemistry

Amino AcidsMolecular RegulationIsolated Pancreatic IsletsGlycobiologyS6 Kinase +21

Metabolic Regulation by Leucine of Translation Initiation Through the mTOR-Signaling Pathway by Pancreatic β-Cells

Guang Xu, Guim Kwon, Wilhelm S. Cruz, +2

Diabetes

Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors

Guang Xu, Wanghai Zhang, Paula Bertram, +2

International Journal of Oncology

Low PtenChemoprevention StrategyRapamycin AnalogueMtor InhibitionMedicine +13

Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects

J. Serpa Morán, Lionel Cohen, J M Greene, +4

American Journal of Clinical Nutrition

HypertensionPhysiologyHuman SubjectsCardiovascular PharmacodynamicsMedicine +2

Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways

Chunliu Mi, Juan Ma, Ke Si Wang, +8

Journal of Ethnopharmacology

OncologyMedicineCancer Cell BiologyMapk PathwaysCell Biology +6

Insulin Mediates Glucose-stimulated Phosphorylation of PHAS-I by Pancreatic Beta Cells

Guang Xu, Connie A. Marshall, Tai-An Lin, +5

Journal of Biological Chemistry

The kinetics and tissue distribution of protein transduction in mice

Shi-Rong Cai, Guang Xu, Michelle Becker‐Hapak, +3

European Journal of Pharmaceutical Sciences

Knockout MouseProtein FunctionSignal TransductionProtein TransductionBiochemistry +9

Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells

Zhe Wang, Ming Yue Li, Zhi Hong Zhang, +11

Pharmacological Research

Tumor BiologyHypoxia-inducible FactorOncologyChemoprevention StrategyMedicine +8

Artemisinin inhibits inflammatory response <i>via</i> regulating NF-κB and MAPK signaling pathways

Ke Si Wang, Junbo Li, Zhe Wang, +6

Immunopharmacology and Immunotoxicology

Inflammatory Lung DiseaseImmune RegulationImmunologyCell DeathTpa-induced Skin Inflammation +18