Concepedia

Isozyme Selectivity

Isozyme Selectivity is a biochemical targeting principle that distinguishes between structurally similar isozymes of an enzyme, such as glutamine synthetase, by selectively inhibiting or modulating one isozyme variant while minimizing effects on others within the same enzyme family.

176

Publications

11.4K

Citations

869

Authors

223

Institutions

Publications per year

2017–2026

19

Parents

Publications

176

Anchoring proteins for protein kinase C: a means for isozyme selectivity

Daria Mochly‐Rosen, Adrienne S. Gordon · The FASEB Journal · 1998 · 578 citations

, , +17

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Benjamin Lauffer, Robert Mintzer, Rina Fong et al. · Journal of Biological Chemistry · 2013 · 412 citations · Full text

, , +15

Human Serum Paraoxonase (pon1) Isozymes Q and R Hydrolyze Lactones and Cyclic Carbonate Esters

Scott S. Billecke, Dragomir Draganov, Raymond E. Counsell et al. · Drug Metabolism and Disposition · 2000 · 400 citations

, , +11

A Protein Kinase C Translocation Inhibitor as an Isozyme-selective Antagonist of Cardiac Function

John A. Johnson, Mary O. Gray, Che-Hong Chen et al. · Journal of Biological Chemistry · 1996 · 381 citations · Full text

, , +14

Metabolism and bioactivation of clozapine by human liver in vitro.

Munir Pirmohamed, Dominic P. Williams, Stephen F. Madden et al. · Journal of Pharmacology and Experimental Therapeutics · 1995 · 271 citations

, , +16

1–5 of 176

Authors

869

  1. CT
    Claudiu T. Supuran

    University of Florence, Italy

    10 publications · 699 citations

    10

    h-index

  2. DM
    Daria Mochly‐Rosen

    Stanford University, United States

    7 publications · 1.4K citations

    7

    h-index

  3. AS
    Andrea Scozzafava

    University of Florence, Italy

    6 publications · 528 citations

    6

    h-index

  4. JR
    John R. Bend

    National Institute of Environmental Health Sciences, United States

    5 publications · 144 citations

    5

    h-index

  5. PM
    Pavel Martásek

    Charles University, Czechia

    4 publications · 228 citations

    4

    h-index

1–5 of 869

Institutions

223

  1. University of Florence

    Florence, Italy

    11 h-index

    47 publications

    3.3K citations

  2. Stanford University

    Stanford, United States

    7 h-index

    14 publications

    2.8K citations

  3. University of Washington

    Seattle, United States

    5 h-index

    11 publications

    547 citations

  4. Harvard University

    Cambridge, United States

    5 h-index

    22 publications

    1.5K citations

  5. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    4 h-index

    18 publications

    1.4K citations

  6. University of Pennsylvania

    Philadelphia, United States

    4 h-index

    12 publications

    1K citations

  7. Charles University

    Prague, Czechia

    4 h-index

    4 publications

    228 citations

  8. University of Toronto

    Toronto, Canada

    4 h-index

    13 publications

    375 citations

1–8 of 223

Venues

  1. Journal of Medicinal Chemistry

    26 publications · 1.5K citations

    22

    h-index

  2. Journal of Biological Chemistry

    JBC · 14 publications · 1.8K citations

    14

    h-index

  3. Molecular Pharmacology

    9 publications · 343 citations

    9

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    6 publications · 231 citations

    6

    h-index

  5. PubMed

    Repository · 6 publications · 183 citations

    6

    h-index

1–5